| 13. Round | 23/01/2021 | Tuzos de la UAZ | - | Gavilanes de Matamoros | 2:0 | ||||
| 14. Round | 30/01/2021 | Gavilanes de Matamoros | - | Alacranes de Durango | 1:0 | ||||
| 15. Round | 06/02/2021 | Cimarrones de Sonora II | - | Gavilanes de Matamoros | 0:1 |  |
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| 16. Round | 12/02/2021 | Gavilanes de Matamoros | - | Saltillo FC | 2:1 |  |
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| 17. Round | 22/02/2021 | Leones Negros II | - | Gavilanes de Matamoros | 0:1 | ||||
| 18. Round | 06/03/2021 | Gavilanes de Matamoros | - | Tecos Fútbol Club | 1:0 | |
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| 19. Round | 13/03/2021 | Mineros de Fresnillo FC | - | Gavilanes de Matamoros | 1:1 | ||||
| 20. Round | 20/03/2021 | Gavilanes de Matamoros | - | Mazorqueros | 1:0 | ||||
| 21. Round | 03/04/2021 | Atlético San Luis II | - | Gavilanes de Matamoros | 1:1 | |
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| 22. Round | 10/04/2021 | Gavilanes de Matamoros | - | Reboceros de La Piedad | 3:0 | |
Mexico