| 6. Round | 26/07/2022 | Nacional Potosí | - | Real Santa Cruz | 3:1 | ||||
| 19. Round | 30/09/2022 | Real Santa Cruz | - | Real Tomayapo | 1:1 | ||||
| 20. Round | 06/10/2022 | Oriente Petrolero | - | Real Santa Cruz | 3:1 | ||||
| 21. Round | 08/10/2022 | Real Santa Cruz | - | Nacional Potosí | 2:1 | ||||
| 22. Round | 13/10/2022 | Club Aurora | - | Real Santa Cruz | 1:2 | ||||
| 23. Round | 16/10/2022 | Real Santa Cruz | - | Always Ready | 1:0 | ||||
| 24. Round | 19/10/2022 | The Strongest | - | Real Santa Cruz | 5:2 |
Bolivia