2. Round | 15/01/2023 | Santos Laguna | - | Pumas UNAM | 3:0 | ||||
3. Round | 21/01/2023 | Mazatlán FC | - | Santos Laguna | 1:2 | ||||
8. Round | 18/02/2023 | Atlético San Luis | - | Santos Laguna | 1:1 | ||||
9. Round | 27/02/2023 | Santos Laguna | - | Puebla FC | 3:2 | ||||
11. Round | 13/03/2023 | Santos Laguna | - | Club Tijuana | 3:2 | ||||
14. Round | 10/04/2023 | Santos Laguna | - | CF Pachuca | 1:4 | ||||
15. Round | 17/04/2023 | CF Monterrey | - | Santos Laguna | 1:2 | ||||
16. Round | 24/04/2023 | Santos Laguna | - | Gallos Blancos | 0:2 |