| 1. Round | 13/08/2021 | Valencia CF | - | Getafe CF | 1:0 | ||||
| 2. Round | 23/08/2021 | Getafe CF | - | Sevilla FC | 0:1 | ||||
| 3. Round | 29/08/2021 | FC Barcelona | - | Getafe CF | 2:1 | ||||
| 5. Round | 18/09/2021 | Rayo Vallecano | - | Getafe CF | 3:0 |  |
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| 6. Round | 21/09/2021 | Getafe CF | - | Atlético Madrid | 1:2 | ||||
| 7. Round | 26/09/2021 | Real Betis | - | Getafe CF | 2:0 | ||||
| 8. Round | 03/10/2021 | Getafe CF | - | Real Sociedad | 1:1 |
Mexico