| Zona B | 21/02/2021 | Cobán Imperial | - | CSD Municipal | 1:0 | ||||
| Zona B | 27/02/2021 | CSD Municipal | - | Deportivo Guastatoya | 0:1 | ||||
| Zona B | 03/03/2021 | CSD Municipal | - | Sanarate | 3:1 | ||||
| Zona B | 07/03/2021 | Achuapa | - | CSD Municipal | 1:2 | ||||
| Zona B | 10/03/2021 | CSD Municipal | - | Sacachispas | 1:2 | ||||
| Zona B | 13/03/2021 | CSD Municipal | - | Cobán Imperial | 2:0 |  |
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| Zona B | 01/04/2021 | Deportivo Guastatoya | - | CSD Municipal | 0:0 | ||||
| Zona B | 04/04/2021 | Sanarate | - | CSD Municipal | 2:1 | |
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| Zona B | 07/04/2021 | CSD Municipal | - | Achuapa | 3:0 | |
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| Zona B | 11/04/2021 | Sacachispas | - | CSD Municipal | 0:3 | |
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| Interzone | 14/04/2021 | CSD Municipal | - | Deportivo Malacateco | 3:0 | ||||
| Interzone | 18/04/2021 | Antigua GFC | - | CSD Municipal | 1:1 | ||||
| Interzone | 21/04/2021 | CSD Municipal | - | Comunicaciones | 0:1 | ||||
| Interzone | 24/04/2021 | Iztapa | - | CSD Municipal | 0:0 |  |
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| Interzone | 28/04/2021 | CSD Municipal | - | Santa Lucía | 2:1 | ||||
| Interzone | 02/05/2021 | Xelaju MC | - | CSD Municipal | 0:3 | ||||
| Quarter-finals | 06/05/2021 | Iztapa | - | CSD Municipal | 3:1 | |
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| Quarter-finals | 09/05/2021 | CSD Municipal | - | Iztapa | 0:0 |
Guatemala