| 2. Round | 10/07/2022 | Club León [U20] | - | Pumas UNAM [U20] | 3:2 | ||||
| 4. Round | 24/07/2022 | CF Pachuca [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 5. Round | 27/07/2022 | Pumas UNAM [U20] | - | Mazatlán FC [U20] | 5:0 |  |
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| 6. Round | 30/07/2022 | Pumas UNAM [U20] | - | CF Monterrey [U20] | 2:0 | |
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| 7. Round | 06/08/2022 | Puebla FC [U20] | - | Pumas UNAM [U20] | 1:2 | ||||
| 8. Round | 13/08/2022 | Pumas UNAM [U20] | - | CF América [U20] | 1:1 | ||||
| 10. Round | 21/08/2022 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 0:1 | ||||
| 16. Round | 24/08/2022 | Pumas UNAM [U20] | - | UANL Tigres [U20] | 1:1 | |
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| 11. Round | 27/08/2022 | Deportivo Guadalajara [U20] | - | Pumas UNAM [U20] | 0:1 | ||||
| 12. Round | 03/09/2022 | Atlas Guadalajara [U20] | - | Pumas UNAM [U20] | 1:0 | ||||
| 14. Round | 10/09/2022 | Deportivo Toluca [U20] | - | Pumas UNAM [U20] | 1:2 | ||||
| 17. Round | 30/09/2022 | FC Juárez [U20] | - | Pumas UNAM [U20] | 3:0 |
Mexico