| 1. Round | 20/08/2017 | Liverpool | - | River Plate | 0:4 | ||||
| 2. Round | 26/08/2017 | River Plate | - | Boston River | 1:1 |  |
|||
| 3. Round | 02/09/2017 | Montevideo Wanderers | - | River Plate | 2:2 |  |
|||
| 5. Round | 16/09/2017 | Fénix | - | River Plate | 0:0 | ||||
| 6. Round | 23/09/2017 | River Plate | - | Rampla Juniors | 3:1 | |
|||
| 9. Round | 08/11/2017 | Juventud de Las Piedras | - | River Plate | 1:0 | ||||
| 14. Round | 26/11/2017 | Racing | - | River Plate | 0:0 |
Uruguay