| 1. Round | 21/07/2018 | Boston River | - | River Plate | 2:3 |  |
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| 5. Round | 19/08/2018 | Torque | - | River Plate | 3:0 | ||||
| 6. Round | 26/08/2018 | River Plate | - | Rampla Juniors | 3:4 | ||||
| 7. Round | 01/09/2018 | Fénix | - | River Plate | 1:3 | ||||
| 8. Round | 09/09/2018 | River Plate | - | Nacional | 0:0 | ||||
| 10. Round | 23/09/2018 | River Plate | - | Defensor Sporting | 3:2 | ||||
| 13. Round | 21/10/2018 | River Plate | - | Montevideo Wanderers | 0:5 |
Uruguay