| 1. Round | 16/01/2022 | Montañeses FC | - | Deportivo Dongu | 3:0 |  |
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| 2. Round | 22/01/2022 | Deportivo Dongu | - | Leviatán FC | 2:1 |  |
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| 3. Round | 29/01/2022 | Sporting Canamy | - | Deportivo Dongu | 2:1 | |
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| 4. Round | 05/02/2022 | Deportivo Dongu | - | Yalmakan FC | 0:2 |  |
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| 6. Round | 19/02/2022 | Deportivo Dongu | - | Reboceros de La Piedad | 0:4 | ||||
| 7. Round | 26/02/2022 | Deportivo Dongu | - | Inter Playa | 1:4 | |
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| 8. Round | 05/03/2022 | Cañoneros FC | - | Deportivo Dongu | 1:0 | |
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| 10. Round | 19/03/2022 | Escorpiones | - | Deportivo Dongu | 5:3 | |
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| 11. Round | 26/03/2022 | Deportivo Dongu | - | Cafetaleros de Chiapas | 1:2 | |
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| 12. Round | 03/04/2022 | CD Zap | - | Deportivo Dongu | 2:1 | |
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| 13. Round | 09/04/2022 | Deportivo Dongu | - | Inter de Querétaro | 6:1 | |
Mexico