| 3. Round | 02/10/2020 | Saltillo FC | - | Atlético San Luis II | 1:3 | ||||
| 5. Round | 15/10/2020 | Tecos Fútbol Club | - | Atlético San Luis II | 2:0 | ||||
| 6. Round | 24/10/2020 | Atlético San Luis II | - | Mineros de Fresnillo FC | 1:0 | ||||
| 7. Round | 09/11/2020 | Mazorqueros | - | Atlético San Luis II | 1:0 | ||||
| 8. Round | 14/11/2020 | Atlético San Luis II | - | Colima FC | 2:0 | ||||
| 9. Round | 23/11/2020 | Atlético San Luis II | - | Reboceros de La Piedad | 0:2 | ||||
| 19. Round | 14/03/2021 | Colima FC | - | Atlético San Luis II | 2:0 | ||||
| 20. Round | 21/03/2021 | Reboceros de La Piedad | - | Atlético San Luis II | 1:0 |
Mexico