| 1. Round | 13/07/2019 | Guaraní | - | River Plate | 1:3 | ||||
| 2. Round | 20/07/2019 | Libertad | - | Guaraní | 1:0 |  |
|||
| 4. Round | 04/08/2019 | Cerro Porteño | - | Guaraní | 2:2 | ||||
| 5. Round | 11/08/2019 | Guaraní | - | Deportivo Santaní | 2:1 |  |
|||
| 6. Round | 18/08/2019 | Deportivo Capiatá | - | Guaraní | 1:2 | |
|||
| 7. Round | 24/08/2019 | Guaraní | - | San Lorenzo | 3:1 | |
|||
| 8. Round | 01/09/2019 | Guaraní | - | General Díaz | 5:0 | |
|||
| 10. Round | 22/09/2019 | Guaraní | - | Club Olimpia | 1:1 | ||||
| 11. Round | 25/09/2019 | Club Nacional | - | Guaraní | 0:2 | ||||
| 12. Round | 28/09/2019 | River Plate | - | Guaraní | 0:1 | ||||
| 13. Round | 05/10/2019 | Guaraní | - | Libertad | 1:1 | ||||
| 14. Round | 20/10/2019 | Sportivo Luqueño | - | Guaraní | 1:0 | ||||
| 15. Round | 27/10/2019 | Guaraní | - | Cerro Porteño | 1:2 | |
|||
| 16. Round | 31/10/2019 | Deportivo Santaní | - | Guaraní | 2:1 | ||||
| 18. Round | 10/11/2019 | San Lorenzo | - | Guaraní | 0:0 | ||||
| 17. Round | 24/11/2019 | Guaraní | - | Deportivo Capiatá | 2:1 | ||||
| 19. Round | 28/11/2019 | General Díaz | - | Guaraní | 0:3 | |
|||
| 20. Round | 01/12/2019 | Guaraní | - | Sol de América | 0:1 | ||||
| 21. Round | 08/12/2019 | Club Olimpia | - | Guaraní | 2:2 | |
|||
| 22. Round | 15/12/2019 | Guaraní | - | Club Nacional | 0:5 | |
Paraguay