| 6. Round | 12/02/2022 | Puebla FC [U16] | - | Deportivo Toluca [U16] | 1:2 | ||||
| 1. Round | 15/02/2022 | FC Juárez [U16] | - | Deportivo Toluca [U16] | 3:1 | ||||
| 8. Round | 26/02/2022 | CF América [U16] | - | Deportivo Toluca [U16] | 0:4 | ||||
| 9. Round | 05/03/2022 | Deportivo Toluca [U16] | - | CF Pachuca [U16] | 1:1 | ||||
| 10. Round | 12/03/2022 | Deportivo Toluca [U16] | - | Puebla FC [U16] | 3:4 | ||||
| 12. Round | 26/03/2022 | Deportivo Toluca [U16] | - | Gallos Blancos [U16] | 2:0 | ||||
| 13. Round | 02/04/2022 | Cruz Azul [U16] | - | Deportivo Toluca [U16] | 0:1 | ||||
| 14. Round | 10/04/2022 | Deportivo Toluca [U16] | - | FC Juárez [U16] | 7:0 | ||||
| 15. Round | 16/04/2022 | Deportivo Toluca [U16] | - | CF América [U16] | 1:2 | ||||
| 16. Round | 23/04/2022 | Pumas UNAM [U16] | - | Deportivo Toluca [U16] | 3:4 |  |
Mexico