| 1. Round | 20/07/2001 | Santos Laguna | - | Atlas Guadalajara | 3:1 | ||||
| 5. Round | 10/09/2001 | Santos Laguna | - | Pumas UNAM | 1:0 |  |
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| 10. Round | 21/09/2001 | Atletico Celaya | - | Santos Laguna | 1:3 | ||||
| 4. Round | 25/09/2001 | Cruz Azul | - | Santos Laguna | 0:0 | ||||
| 12. Round | 04/10/2001 | UAG Tecos | - | Santos Laguna | 1:2 | ||||
| 13. Round | 12/10/2001 | Puebla FC | - | Santos Laguna | 2:1 | ||||
| 18. Round | 16/11/2001 | Santos Laguna | - | UANL Tigres | 1:2 | |
Mexico