1. Round | 08/01/2022 | Club Tijuana [] | - | Club León [] | 3:2 | ||||
2. Round | 15/01/2022 | Club León [] | - | UANL Tigres [] | 1:3 | ||||
3. Round | 22/01/2022 | Deportivo Guadalajara [] | - | Club León [] | 4:0 | ||||
5. Round | 05/02/2022 | CF Monterrey [] | - | Club León [] | 1:0 | ||||
8. Round | 26/02/2022 | Atlas Guadalajara [] | - | Club León [] | 4:1 | ||||
9. Round | 05/03/2022 | Club León [] | - | Mazatlán FC [] | 1:1 | ||||
16. Round | 23/04/2022 | Club León [] | - | Club Tijuana [] | 2:1 | ||||
15. Round | 03/05/2022 | Atlético San Luis [] | - | Club León [] | 0:3 | ||||
18. Round | 07/05/2022 | Santos Laguna [] | - | Club León [] | 2:3 |