| 1. Round | 02/07/2022 | UANL Tigres [U18] | - | Cruz Azul [U18] | 2:1 |  |
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| 2. Round | 09/07/2022 | Cruz Azul [U18] | - | CF Pachuca [U18] | 1:0 | ||||
| 3. Round | 16/07/2022 | Atlas Guadalajara [U18] | - | Cruz Azul [U18] | 2:1 | ||||
| 4. Round | 23/07/2022 | Cruz Azul [U18] | - | Puebla FC [U18] | 2:1 | ||||
| 5. Round | 26/07/2022 | Atlético San Luis [U18] | - | Cruz Azul [U18] | 0:0 | ||||
| 7. Round | 06/08/2022 | Santos Laguna [U18] | - | Cruz Azul [U18] | 2:1 | ||||
| 8. Round | 14/08/2022 | Cruz Azul [U18] | - | Deportivo Toluca [U18] | 1:1 | ||||
| 9. Round | 17/08/2022 | Cruz Azul [U18] | - | Club Tijuana [U18] | 1:1 | ||||
| 10. Round | 20/08/2022 | CF América [U18] | - | Cruz Azul [U18] | 2:0 | ||||
| 16. Round | 24/08/2022 | Cruz Azul [U18] | - | Club León [U18] | 1:0 | ||||
| 11. Round | 27/08/2022 | Cruz Azul [U18] | - | Gallos Blancos [U18] | 1:2 | ||||
| 12. Round | 02/09/2022 | FC Juárez [U18] | - | Cruz Azul [U18] | 0:1 | ||||
| 15. Round | 18/09/2022 | Pumas UNAM [U18] | - | Cruz Azul [U18] | 0:0 | ||||
| 17. Round | 01/10/2022 | Cruz Azul [U18] | - | Deportivo Guadalajara [U18] | 0:4 |
Venezuela
Mexico