| 1. Round | 06/01/2013 | Club León | - | Gallos Blancos (old) | 2:2 | ||||
| 2. Round | 13/01/2013 | Club Tijuana | - | Club León | 1:0 | ||||
| 3. Round | 19/01/2013 | Club León | - | Deportivo Toluca | 1:2 | ||||
| 4. Round | 26/01/2013 | Santos Laguna | - | Club León | 2:0 | ||||
| 5. Round | 03/02/2013 | Club León | - | Cruz Azul | 2:2 |  |
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| 6. Round | 09/02/2013 | Monarcas Morelia | - | Club León | 1:0 | ||||
| 7. Round | 17/02/2013 | Club León | - | Club San Luis | 2:0 | ||||
| 8. Round | 24/02/2013 | Deportivo Guadalajara | - | Club León | 2:1 | |
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| 9. Round | 03/03/2013 | Club León | - | Puebla FC | 0:1 | ||||
| 10. Round | 10/03/2013 | CF Monterrey | - | Club León | 2:1 | ||||
| 12. Round | 31/03/2013 | Club León | - | CF Pachuca | 0:0 | ||||
| 13. Round | 07/04/2013 | UANL Tigres | - | Club León | 0:0 | ||||
| 14. Round | 14/04/2013 | Club León | - | CF América | 1:1 | ||||
| 15. Round | 20/04/2013 | Jaguares Chiapas | - | Club León | 2:2 | ||||
| 16. Round | 28/04/2013 | Club León | - | Atlante | 1:0 | ||||
| 17. Round | 05/05/2013 | Atlas Guadalajara | - | Club León | 0:1 |
Mexico