| 3. Round | 06/08/2017 | Deportivo Guadalajara | - | Club Necaxa | 2:2 | ||||
| 4. Round | 13/08/2017 | CF Monterrey | - | Deportivo Guadalajara | 4:1 | ||||
| 5. Round | 20/08/2017 | Deportivo Guadalajara | - | Puebla FC | 0:1 | ||||
| 6. Round | 24/08/2017 | Santos Laguna | - | Deportivo Guadalajara | 1:1 | ||||
| 7. Round | 27/08/2017 | Deportivo Guadalajara | - | Gallos Blancos | 0:0 | ||||
| 8. Round | 10/09/2017 | CF Pachuca | - | Deportivo Guadalajara | 1:3 | ||||
| 9. Round | 17/09/2017 | Deportivo Guadalajara | - | Pumas UNAM | 1:1 | ||||
| 11. Round | 27/09/2017 | Deportivo Guadalajara | - | Lobos BUAP | 1:2 | ||||
| 12. Round | 01/10/2017 | UANL Tigres | - | Deportivo Guadalajara | 1:0 |  |
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| 13. Round | 15/10/2017 | Deportivo Guadalajara | - | Monarcas Morelia | 1:2 | |
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| 10. Round | 19/10/2017 | CF América | - | Deportivo Guadalajara | 2:1 | |
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| 16. Round | 05/11/2017 | Deportivo Guadalajara | - | Atlas Guadalajara | 1:2 | ||||
| 17. Round | 19/11/2017 | Club León | - | Deportivo Guadalajara | 0:2 |
Mexico