| 1. Round | 26/07/2020 | Deportivo Guadalajara | - | Club León | 0:0 | ||||
| 2. Round | 03/08/2020 | Santos Laguna | - | Deportivo Guadalajara | 2:0 |  |
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| 4. Round | 13/08/2020 | FC Juárez | - | Deportivo Guadalajara | 0:2 | ||||
| 8. Round | 06/09/2020 | UANL Tigres | - | Deportivo Guadalajara | 1:3 | ||||
| 9. Round | 09/09/2020 | Deportivo Guadalajara | - | Gallos Blancos | 1:1 | ||||
| 10. Round | 12/09/2020 | Club Necaxa | - | Deportivo Guadalajara | 1:2 | ||||
| 11. Round | 20/09/2020 | CF América | - | Deportivo Guadalajara | 1:0 | ||||
| 12. Round | 26/09/2020 | Deportivo Guadalajara | - | Mazatlán FC | 2:1 | ||||
| 13. Round | 05/10/2020 | Club Tijuana | - | Deportivo Guadalajara | 0:0 | ||||
| 14. Round | 18/10/2020 | Deportivo Guadalajara | - | Atlas Guadalajara | 3:2 |
Mexico