| 1. Round | 16/01/2022 | Yalmakan FC | - | Inter Playa | 0:0 | ||||
| 2. Round | 23/01/2022 | Lobos ULMX | - | Yalmakan FC | 0:1 | ||||
| 3. Round | 30/01/2022 | Yalmakan FC | - | Reboceros de La Piedad | 0:0 | ||||
| 4. Round | 05/02/2022 | Deportivo Dongu | - | Yalmakan FC | 0:2 | ||||
| 5. Round | 13/02/2022 | Yalmakan FC | - | Cañoneros FC | 3:0 | ||||
| 7. Round | 27/02/2022 | Yalmakan FC | - | Escorpiones | 0:1 | ||||
| 8. Round | 05/03/2022 | Cafetaleros de Chiapas | - | Yalmakan FC | 1:0 | ||||
| 9. Round | 13/03/2022 | Yalmakan FC | - | CD Zap | 1:1 |  |
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| 10. Round | 19/03/2022 | Inter de Querétaro | - | Yalmakan FC | 0:2 | ||||
| 13. Round | 10/04/2022 | Yalmakan FC | - | Sporting Canamy | 2:0 |
Mexico