| 1. Round | 22/02/2025 | Los Angeles FC | - | Minnesota United FC | 1:0 | ||||
| 5. Round | 22/03/2025 | Minnesota United FC | - | Los Angeles Galaxy | 2:2 | ||||
| 6. Round | 30/03/2025 | Minnesota United FC | - | Real Salt Lake | 2:0 | ||||
| 7. Round | 06/04/2025 | New York City FC | - | Minnesota United FC | 1:2 | ||||
| 8. Round | 12/04/2025 | Toronto FC | - | Minnesota United FC | 0:0 | ||||
| 9. Round | 20/04/2025 | Minnesota United FC | - | FC Dallas | 0:0 |  |
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| 10. Round | 27/04/2025 | Minnesota United FC | - | Vancouver Whitecaps | 1:3 | ||||
| 11. Round | 04/05/2025 | Austin FC | - | Minnesota United FC | 0:3 | ||||
| 12. Round | 10/05/2025 | Minnesota United FC | - | Inter Miami CF | 4:1 | ||||
| 15. Round | 25/05/2025 | Minnesota United FC | - | Austin FC | 1:1 | ||||
| 16. Round | 29/05/2025 | Vancouver Whitecaps | - | Minnesota United FC | 0:0 | ||||
| 17. Round | 01/06/2025 | Seattle Sounders | - | Minnesota United FC | 2:3 |
Honduras