| 1. Round | 18/03/2021 | Chacaritas FC | - | Independiente Juniors | 1:4 | ||||
| 2. Round | 26/03/2021 | El Nacional | - | Chacaritas FC | 3:0 |  |
|||
| 3. Round | 01/04/2021 | Chacaritas FC | - | Gualaceo SC | 2:0 | ||||
| 4. Round | 06/04/2021 | Atlético Porteño | - | Chacaritas FC | 1:3 | |
|||
| 5. Round | 14/04/2021 | Chacaritas FC | - | Atlético Santo Domingo | 1:0 | |
|||
| 7. Round | 06/05/2021 | Chacaritas FC | - | Liga de Portoviejo | 2:2 | ||||
| 18. Round | 27/06/2021 | Independiente Juniors | - | Chacaritas FC | 3:2 | ||||
| 23. Round | 18/07/2021 | El Nacional | - | Chacaritas FC | 1:0 | |
|||
| 28. Round | 18/08/2021 | Atlético Santo Domingo | - | Chacaritas FC | 0:0 | |
|||
| 31. Round | 08/09/2021 | Chacaritas FC | - | El Nacional | 1:1 | ||||
| 35. Round | 06/10/2021 | Liga de Portoviejo | - | Chacaritas FC | 1:0 | ||||
| 36. Round | 13/10/2021 | Chacaritas FC | - | América de Quito | 2:2 |
Ecuador