| 2. Round | 25/03/2021 | Atlético Santo Domingo | - | América de Quito | 1:1 | ||||
| 5. Round | 14/04/2021 | Chacaritas FC | - | Atlético Santo Domingo | 1:0 |  |
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| 8. Round | 13/05/2021 | El Nacional | - | Atlético Santo Domingo | 1:0 | ||||
| 17. Round | 23/06/2021 | Liga de Portoviejo | - | Atlético Santo Domingo | 2:0 | ||||
| 18. Round | 27/06/2021 | Atlético Santo Domingo | - | Atlético Porteño | 2:1 | ||||
| 19. Round | 03/07/2021 | Atlético Santo Domingo | - | Gualaceo SC | 1:4 |
Ecuador