| 1. Round | 20/02/2022 | Delfín SC | - | Barcelona | 0:1 | ||||
| 2. Round | 26/02/2022 | Aucas | - | Delfín SC | 3:0 | ||||
| 3. Round | 06/03/2022 | Delfín SC | - | Macará | 1:0 |  |
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| 4. Round | 15/03/2022 | Guayaquil City | - | Delfín SC | 1:1 | ||||
| 5. Round | 21/03/2022 | Emelec | - | Delfín SC | 1:2 | |
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| 6. Round | 04/04/2022 | Delfín SC | - | Deportivo Cuenca | 0:0 | ||||
| 7. Round | 09/04/2022 | Mushuc Runa | - | Delfín SC | 1:2 | ||||
| 8. Round | 16/04/2022 | Delfín SC | - | Cumbayá | 1:1 | ||||
| 9. Round | 20/04/2022 | Técnico Universitario | - | Delfín SC | 1:1 | ||||
| 10. Round | 24/04/2022 | Delfín SC | - | Independiente del Valle | 0:1 |
Ecuador