| 1. Round | 03/07/2022 | Atlético San Luis [U18] | - | Club León [U18] | 1:1 | ||||
| 3. Round | 15/07/2022 | Puebla FC [U18] | - | Club León [U18] | 4:2 | ||||
| 4. Round | 20/07/2022 | Deportivo Guadalajara [U18] | - | Club León [U18] | 2:2 | ||||
| 9. Round | 18/08/2022 | Santos Laguna [U18] | - | Club León [U18] | 3:2 | ||||
| 10. Round | 21/08/2022 | CF Pachuca [U18] | - | Club León [U18] | 0:1 | ||||
| 16. Round | 24/08/2022 | Cruz Azul [U18] | - | Club León [U18] | 1:0 | ||||
| 11. Round | 28/08/2022 | Club León [U18] | - | Atlas Guadalajara [U18] | 1:3 | ||||
| 14. Round | 10/09/2022 | UANL Tigres [U18] | - | Club León [U18] | 3:1 | ||||
| 15. Round | 18/09/2022 | Club León [U18] | - | Gallos Blancos [U18] | 1:1 | ||||
| 8. Round | 27/09/2022 | Club León [U18] | - | Mazatlán FC [U18] | 2:2 |  |
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| 17. Round | 02/10/2022 | Club León [U18] | - | Club Tijuana [U18] | 0:1 |  |
Mexico