| 1. Round | 09/01/2021 | CF América [U20] | - | Atlético San Luis [U20] | 4:1 | ||||
| 2. Round | 15/01/2021 | Club Necaxa [U20] | - | Atlético San Luis [U20] | 2:1 | ||||
| 3. Round | 21/01/2021 | Atlético San Luis [U20] | - | Deportivo Guadalajara [U20] | 3:2 | ||||
| 12. Round | 20/03/2021 | Atlético San Luis [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 14. Round | 09/04/2021 | FC Juárez [U20] | - | Atlético San Luis [U20] | 2:2 | ||||
| 15. Round | 17/04/2021 | Atlético San Luis [U20] | - | Puebla FC [U20] | 5:3 |  |
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| 16. Round | 24/04/2021 | Cruz Azul [U20] | - | Atlético San Luis [U20] | 0:1 | ||||
| 17. Round | 29/04/2021 | Atlético San Luis [U20] | - | CF Pachuca [U20] | 2:0 |
Mexico