| 1. Round | 17/02/2022 | Deportes Melipilla | - | Universidad de Concepción | 0:2 | ||||
| 9. Round | 18/04/2022 | San Luis | - | Deportes Melipilla | 2:1 | ||||
| 10. Round | 20/04/2022 | Deportes Melipilla | - | Santiago Wanderers | 2:0 | ||||
| 11. Round | 25/04/2022 | Deportes Temuco | - | Deportes Melipilla | 1:1 | ||||
| 13. Round | 08/05/2022 | Fernández Vial | - | Deportes Melipilla | 1:1 | ||||
| 14. Round | 12/05/2022 | Deportes Melipilla | - | CD Magallanes | 1:2 | ||||
| 15. Round | 16/05/2022 | Santiago Morning | - | Deportes Melipilla | 1:1 | ||||
| 16. Round | 22/05/2022 | Deportes Melipilla | - | Santa Cruz | 1:0 | ||||
| 17. Round | 29/05/2022 | Deportes Iquique | - | Deportes Melipilla | 3:0 | ||||
| 18. Round | 05/07/2022 | Universidad de Concepción | - | Deportes Melipilla | 1:1 | ||||
| 19. Round | 12/07/2022 | Deportes Melipilla | - | Rangers | 1:2 | ||||
| 20. Round | 19/07/2022 | Puerto Montt | - | Deportes Melipilla | 2:0 |  |
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| 22. Round | 02/08/2022 | Deportes Copiapó | - | Deportes Melipilla | 2:1 | ||||
| 26. Round | 31/08/2022 | Deportes Melipilla | - | San Luis | 1:2 | ||||
| 30. Round | 03/10/2022 | Deportes Melipilla | - | Fernández Vial | 2:2 | ||||
| 32. Round | 17/10/2022 | Deportes Melipilla | - | Santiago Morning | 2:1 |
Chile