| 1. Round | 18/09/2021 | Cañoneros FC | - | Inter de Querétaro | 0:1 | ||||
| 3. Round | 02/10/2021 | Escorpiones | - | Inter de Querétaro | 1:1 | ||||
| 4. Round | 09/10/2021 | Inter de Querétaro | - | Cafetaleros de Chiapas | 0:2 | ||||
| 8. Round | 01/11/2021 | Leviatán FC | - | Inter de Querétaro | 0:3 | ||||
| 9. Round | 06/11/2021 | Inter de Querétaro | - | Sporting Canamy | 1:0 | ||||
| 11. Round | 13/11/2021 | Inter de Querétaro | - | Lobos ULMX | 1:1 | ||||
| 12. Round | 21/11/2021 | Reboceros de La Piedad | - | Inter de Querétaro | 1:0 |
Mexico