| 1. Round | 22/07/2017 | Spartak Trnava | - | MFK Zemplín Michalovce | 1:0 |  |
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| 2. Round | 29/07/2017 | FC Nitra | - | MFK Zemplín Michalovce | 0:0 | ||||
| 5. Round | 19/08/2017 | AS Trenčín | - | MFK Zemplín Michalovce | 1:2 | ||||
| 6. Round | 26/08/2017 | MFK Zemplín Michalovce | - | Zlaté Moravce | 2:0 | ||||
| 7. Round | 09/09/2017 | MFK Ružomberok | - | MFK Zemplín Michalovce | 2:1 | ||||
| 8. Round | 16/09/2017 | MFK Zemplín Michalovce | - | FK Senica | 2:1 | ||||
| 10. Round | 24/09/2017 | MFK Zemplín Michalovce | - | FC DAC 1904 | 1:2 | ||||
| 11. Round | 30/09/2017 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:1 | ||||
| 14. Round | 28/10/2017 | MFK Zemplín Michalovce | - | FK Železiarne Podbrezová | 2:1 | ||||
| 15. Round | 03/11/2017 | 1. FC Tatran Prešov | - | MFK Zemplín Michalovce | 1:0 | ||||
| 17. Round | 25/11/2017 | Zlaté Moravce | - | MFK Zemplín Michalovce | 0:1 | ||||
| 16. Round | 28/11/2017 | MFK Zemplín Michalovce | - | AS Trenčín | 1:1 | |
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| 18. Round | 02/12/2017 | MFK Zemplín Michalovce | - | MFK Ružomberok | 1:1 | ||||
| 19. Round | 09/12/2017 | FK Senica | - | MFK Zemplín Michalovce | 1:1 | ||||
| 22. Round | 03/03/2018 | MFK Zemplín Michalovce | - | MŠK Žilina | 1:0 | |
Slovakia