| 1. Round | 25/04/2021 | Minnesota United FC | - | Real Salt Lake | 1:2 | ||||
| 2. Round | 09/05/2021 | Colorado Rapids | - | Minnesota United FC | 3:2 | ||||
| 3. Round | 20/06/2021 | FC Dallas | - | Minnesota United FC | 1:1 | ||||
| 3. Round | 24/06/2021 | Minnesota United FC | - | Austin FC | 2:0 | ||||
| 3. Round | 27/06/2021 | Portland Timbers | - | Minnesota United FC | 0:1 | ||||
| 4. Round | 25/07/2021 | Minnesota United FC | - | Portland Timbers | 2:1 | ||||
| 4. Round | 29/07/2021 | Los Angeles FC | - | Minnesota United FC | 2:2 | ||||
| 5. Round | 08/08/2021 | Minnesota United FC | - | Houston Dynamo | 2:0 | ||||
| 5. Round | 14/08/2021 | Minnesota United FC | - | Los Angeles Galaxy | 0:1 | ||||
| 5. Round | 18/08/2021 | San Jose Earthquakes | - | Minnesota United FC | 1:1 | ||||
| 5. Round | 21/08/2021 | Minnesota United FC | - | Sporting Kansas City | 0:0 | ||||
| 6. Round | 30/09/2021 | D.C. United | - | Minnesota United FC | 3:1 | ||||
| 7. Round | 10/10/2021 | Minnesota United FC | - | Colorado Rapids | 1:3 |
Colombia