| 2. Round | 06/08/2011 | Guaraní | - | Club Rubio Ñu | 2:2 | ||||
| 6. Round | 05/09/2011 | Guaraní | - | Sol de América | 3:1 | ||||
| 7. Round | 11/09/2011 | Cerro Porteño | - | Guaraní | 0:1 | ||||
| 9. Round | 24/09/2011 | Independiente CG | - | Guaraní | 1:1 | ||||
| 11. Round | 02/10/2011 | Tacuary | - | Guaraní | 1:2 | ||||
| 12. Round | 14/10/2011 | Club Olimpia | - | Guaraní | 2:0 | ||||
| 13. Round | 23/10/2011 | Club Rubio Ñu | - | Guaraní | 2:2 | ||||
| 15. Round | 06/11/2011 | Libertad | - | Guaraní | 3:2 | ||||
| 19. Round | 30/11/2011 | Sportivo Luqueño | - | Guaraní | 1:5 | ||||
| 21. Round | 10/12/2011 | Club Nacional | - | Guaraní | 5:2 | ||||
| 22. Round | 16/12/2011 | Guaraní | - | Tacuary | 0:0 |
Paraguay