1. Round | 06/02/2022 | Guaireña FC | - | Guaraní | 0:0 | ||||
2. Round | 12/02/2022 | Guaireña FC | - | Club Olimpia | 1:3 | ||||
3. Round | 20/02/2022 | Sol de América | - | Guaireña FC | 1:0 | ||||
4. Round | 27/02/2022 | Guaireña FC | - | Cerro Porteño | 0:2 | ||||
5. Round | 05/03/2022 | Resistencia SC | - | Guaireña FC | 2:2 | ||||
7. Round | 21/03/2022 | General Caballero DJLM | - | Guaireña FC | 0:1 | ||||
8. Round | 02/04/2022 | Guaireña FC | - | Libertad | 2:3 | ||||
11. Round | 20/04/2022 | Club Nacional | - | Guaireña FC | 3:1 | ||||
13. Round | 02/05/2022 | Club Olimpia | - | Guaireña FC | 1:0 | ||||
14. Round | 08/05/2022 | Guaireña FC | - | Sol de América | 2:1 | ||||
15. Round | 12/05/2022 | Cerro Porteño | - | Guaireña FC | 0:0 | ||||
17. Round | 30/05/2022 | 12 de Octubre de Itauguá | - | Guaireña FC | 0:4 | ||||
19. Round | 18/06/2022 | Libertad | - | Guaireña FC | 2:0 |