1. Round | 04/02/2022 | Sol de América | - | Club Nacional | 0:0 | ||||
2. Round | 13/02/2022 | Club Nacional | - | Cerro Porteño | 2:3 | ||||
3. Round | 18/02/2022 | Resistencia SC | - | Club Nacional | 3:1 | ||||
8. Round | 03/04/2022 | Club Nacional | - | Sportivo Ameliano | 2:1 | ||||
11. Round | 20/04/2022 | Club Nacional | - | Guaireña FC | 3:1 | ||||
18. Round | 13/06/2022 | Club Nacional | - | Tacuary | 3:0 |