| 2. Round | 16/01/2022 | Leones Negros | - | Pumas Tabasco | 3:1 | ||||
| 4. Round | 27/01/2022 | Leones Negros | - | Correcaminos UAT | 0:3 | ||||
| 6. Round | 05/02/2022 | Leones Negros | - | Mineros de Zacatecas | 2:3 | ||||
| 9. Round | 23/02/2022 | Leones Negros | - | Venados FC | 0:1 | ||||
| 13. Round | 23/03/2022 | Leones Negros | - | CF Monterrey II | 0:0 |
Mexico