| 2. Round | 14/08/2021 | Victoria Rosport | - | FC Differdange 03 | 0:3 | ||||
| 1. Round | 18/08/2021 | Progrès Niedercorn | - | FC Differdange 03 | 3:0 |  |
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| 3. Round | 22/08/2021 | FC Differdange 03 | - | CS FOLA Esch | 1:1 | ||||
| 4. Round | 29/08/2021 | UNA Strassen | - | FC Differdange 03 | 0:1 | ||||
| 23. Round | 03/04/2022 | F91 Dudelange | - | FC Differdange 03 | 1:0 | |
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| 24. Round | 10/04/2022 | FC Differdange 03 | - | Jeunesse Esch | 1:0 | |
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| 25. Round | 16/04/2022 | US Hostert | - | FC Differdange 03 | 0:0 | ||||
| 26. Round | 24/04/2022 | FC Differdange 03 | - | RFCU Luxemburg | 4:0 | ||||
| 27. Round | 01/05/2022 | Union Titus Pétange | - | FC Differdange 03 | 1:2 | |
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| 28. Round | 08/05/2022 | FC Differdange 03 | - | US Mondorf | 1:0 | ||||
| 29. Round | 15/05/2022 | Etzella Ettelbruck | - | FC Differdange 03 | 0:2 | ||||
| 30. Round | 22/05/2022 | FC Differdange 03 | - | Progrès Niedercorn | 2:0 |
Argentina
Italy