| 1. Round | 03/07/2022 | Atlético San Luis [U18] | - | Club León [U18] | 1:1 | ||||
| 2. Round | 10/07/2022 | Club León [U18] | - | Pumas UNAM [U18] | 1:2 | ||||
| 3. Round | 15/07/2022 | Puebla FC [U18] | - | Club León [U18] | 4:2 |  |
|||
| 4. Round | 20/07/2022 | Deportivo Guadalajara [U18] | - | Club León [U18] | 2:2 | ||||
| 12. Round | 02/09/2022 | Club Necaxa [U18] | - | Club León [U18] | 1:1 | ||||
| 13. Round | 06/09/2022 | Club León [U18] | - | FC Juárez [U18] | 0:0 | ||||
| 14. Round | 10/09/2022 | UANL Tigres [U18] | - | Club León [U18] | 3:1 | ||||
| 7. Round | 13/09/2022 | CF Monterrey [U18] | - | Club León [U18] | 2:0 | ||||
| 15. Round | 18/09/2022 | Club León [U18] | - | Gallos Blancos [U18] | 1:1 | ||||
| 8. Round | 27/09/2022 | Club León [U18] | - | Mazatlán FC [U18] | 2:2 | ||||
| 17. Round | 02/10/2022 | Club León [U18] | - | Club Tijuana [U18] | 0:1 |
Mexico