| 1. Round | 03/03/2018 | Houston Dynamo | - | Atlanta United FC | 4:0 | ||||
| 3. Round | 26/05/2018 | Houston Dynamo | - | New York City FC | 3:1 | ||||
| 7. Round | 16/09/2018 | Houston Dynamo | - | Portland Timbers | 4:1 | ||||
| 7. Round | 23/09/2018 | Orlando City | - | Houston Dynamo | 0:0 | ||||
| 7. Round | 30/09/2018 | Houston Dynamo | - | San Jose Earthquakes | 3:2 | ||||
| 8. Round | 09/10/2018 | Seattle Sounders | - | Houston Dynamo | 4:1 |  |
Colombia