| 3. Round | 21/01/2022 | Atlético San Luis | - | FC Juárez | 0:1 | ||||
| 4. Round | 06/02/2022 | CF América | - | Atlético San Luis | 2:3 | ||||
| 6. Round | 20/02/2022 | UANL Tigres | - | Atlético San Luis | 2:1 | ||||
| 7. Round | 26/02/2022 | CF Monterrey | - | Atlético San Luis | 0:2 | ||||
| 12. Round | 02/04/2022 | Atlético San Luis | - | Mazatlán FC | 1:0 | ||||
| 14. Round | 16/04/2022 | Club Necaxa | - | Atlético San Luis | 4:2 | ||||
| 15. Round | 21/04/2022 | Atlético San Luis | - | Pumas UNAM | 2:0 | ||||
| 16. Round | 24/04/2022 | Cruz Azul | - | Atlético San Luis | 0:1 |
Mexico