| 4. Round | 14/08/2021 | Club Tijuana [U16] | - | FC Juárez [U16] | 1:1 | ||||
| 2. Round | 15/09/2021 | Club Tijuana [U16] | - | Deportivo Toluca [U16] | 3:0 | ||||
| 9. Round | 18/09/2021 | Club Tijuana [U16] | - | Pumas UNAM [U16] | 1:0 | ||||
| 12. Round | 09/10/2021 | Club Tijuana [U16] | - | Puebla FC [U16] | 3:1 | ||||
| 13. Round | 16/10/2021 | CF América [U16] | - | Club Tijuana [U16] | 4:2 | ||||
| 14. Round | 23/10/2021 | Club Tijuana [U16] | - | CF Pachuca [U16] | 0:1 | ||||
| 15. Round | 30/10/2021 | Club Tijuana [U16] | - | Gallos Blancos [U16] | 3:2 | ||||
| 16. Round | 06/11/2021 | FC Juárez [U16] | - | Club Tijuana [U16] | 1:3 | ||||
| 17. Round | 13/11/2021 | Pumas UNAM [U16] | - | Club Tijuana [U16] | 0:0 | ||||
| 18. Round | 20/11/2021 | Club Tijuana [U16] | - | Cruz Azul [U16] | 0:0 |  |
Mexico