| 1. Round | 16/04/2022 | Olmedo [U19] | - | Libertad de Loja [U19] | 2:0 |  |
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| 2. Round | 23/04/2022 | Libertad de Loja [U19] | - | Búhos ULVR [U19] | 3:1 | ||||
| 3. Round | 30/04/2022 | Gualaceo SC [U19] | - | Libertad de Loja [U19] | 3:0 dec. | |
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| 5. Round | 14/05/2022 | Barcelona [U19] | - | Libertad de Loja [U19] | 2:2 | ||||
| 6. Round | 21/05/2022 | Libertad de Loja [U19] | - | Deportivo Cuenca [U19] | 0:3 dec. | ||||
| 7. Round | 27/05/2022 | Orense SC [U19] | - | Libertad de Loja [U19] | 4:0 | |
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| 8. Round | 04/06/2022 | Libertad de Loja [U19] | - | Olmedo [U19] | 1:1 | |
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| 9. Round | 12/06/2022 | Búhos ULVR [U19] | - | Libertad de Loja [U19] | 1:1 | ||||
| 13. Round | 30/07/2022 | Deportivo Cuenca [U19] | - | Libertad de Loja [U19] | 1:0 | |
Ecuador