| 1. Round | 02/02/2018 | Sportivo Luqueño | - | Libertad | 2:2 | ||||
| 2. Round | 10/02/2018 | Libertad | - | Guaraní | 2:0 |  |
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| 3. Round | 16/02/2018 | Deportivo Santaní | - | Libertad | 1:2 | ||||
| 4. Round | 23/02/2018 | Libertad | - | Cerro Porteño | 1:1 | ||||
| 5. Round | 04/03/2018 | 3 de Febrero | - | Libertad | 1:4 |  |
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| 8. Round | 17/03/2018 | Deportivo Capiatá | - | Libertad | 2:4 | ||||
| 7. Round | 21/03/2018 | Club Nacional | - | Libertad | 1:1 | ||||
| 12. Round | 15/04/2018 | Libertad | - | Sportivo Luqueño | 1:2 | ||||
| 14. Round | 30/04/2018 | Libertad | - | Deportivo Santaní | 1:1 | ||||
| 20. Round | 31/05/2018 | Club Olimpia | - | Libertad | 2:1 | ||||
| 22. Round | 09/06/2018 | General Díaz | - | Libertad | 0:2 |
Paraguay