| 9. Round | 15/09/2019 | Club Nacional | - | Deportivo Capiatá | 3:0 | ||||
| 10. Round | 21/09/2019 | San Lorenzo | - | Club Nacional | 0:3 | ||||
| 11. Round | 25/09/2019 | Club Nacional | - | Guaraní | 0:2 | ||||
| 13. Round | 06/10/2019 | Club Olimpia | - | Club Nacional | 3:0 | ||||
| 14. Round | 19/10/2019 | Club Nacional | - | General Díaz | 0:0 | ||||
| 15. Round | 26/10/2019 | Club Nacional | - | River Plate | 1:1 |  |
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| 16. Round | 01/11/2019 | Libertad | - | Club Nacional | 2:0 | ||||
| 18. Round | 10/11/2019 | Cerro Porteño | - | Club Nacional | 5:0 | ||||
| 17. Round | 23/11/2019 | Club Nacional | - | Sportivo Luqueño | 1:1 | ||||
| 19. Round | 26/11/2019 | Club Nacional | - | Deportivo Santaní | 4:0 | ||||
| 20. Round | 02/12/2019 | Deportivo Capiatá | - | Club Nacional | 0:0 | ||||
| 21. Round | 09/12/2019 | Club Nacional | - | San Lorenzo | 4:2 | |
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| 22. Round | 15/12/2019 | Guaraní | - | Club Nacional | 0:5 |
Paraguay