| 1. Round | 17/10/2020 | Club Olimpia | - | Club Nacional | 1:1 |  |
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| 2. Round | 25/10/2020 | San Lorenzo | - | Club Nacional | 1:1 | |
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| 3. Round | 30/10/2020 | Club Nacional | - | 12 de Octubre de Itauguá | 1:1 | ||||
| 4. Round | 08/11/2020 | Sportivo Luqueño | - | Club Nacional | 1:3 | ||||
| 5. Round | 12/11/2020 | Club Nacional | - | Guaraní | 0:0 | ||||
| 6. Round | 15/11/2020 | Libertad | - | Club Nacional | 0:2 | ||||
| 7. Round | 22/11/2020 | Club Nacional | - | Guaireña FC | 0:0 | ||||
| 9. Round | 07/12/2020 | Club Nacional | - | Cerro Porteño | 4:3 | |
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| 10. Round | 12/12/2020 | River Plate | - | Club Nacional | 1:1 |
Paraguay