| 5. Round | 05/03/2022 | River Plate | - | Cerro Largo | 1:1 | ||||
| 6. Round | 20/03/2022 | River Plate | - | Fénix | 3:1 | ||||
| 8. Round | 10/04/2022 | River Plate | - | Albion | 4:1 | ||||
| 13. Round | 22/05/2022 | Liverpool | - | River Plate | 2:1 | ||||
| 14. Round | 29/05/2022 | River Plate | - | Peñarol | 0:0 | ||||
| 15. Round | 03/06/2022 | Montevideo City Torque | - | River Plate | 0:0 |
Uruguay