| 3. Round | 12/08/2022 | Boston River | - | River Plate | 1:2 | ||||
| 6. Round | 20/08/2022 | Fénix | - | River Plate | 1:2 |  |
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| 5. Round | 29/08/2022 | Cerro Largo | - | River Plate | 0:5 | |
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| 4. Round | 05/09/2022 | Cerrito | - | River Plate | 1:5 | |
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| 8. Round | 14/09/2022 | Albion | - | River Plate | 0:2 | ||||
| 9. Round | 17/09/2022 | River Plate | - | Nacional | 1:1 | ||||
| 10. Round | 24/09/2022 | Danubio | - | River Plate | 3:0 | ||||
| 11. Round | 02/10/2022 | River Plate | - | Deportivo Maldonado | 0:0 | ||||
| 12. Round | 08/10/2022 | Rentistas | - | River Plate | 0:5 | ||||
| 13. Round | 13/10/2022 | River Plate | - | Liverpool | 0:1 | ||||
| 14. Round | 16/10/2022 | Peñarol | - | River Plate | 1:1 | ||||
| 15. Round | 21/10/2022 | River Plate | - | Montevideo City Torque | 2:1 |
Uruguay