| 1. Round | 31/01/2010 | River Plate | - | Banfield | 0:1 |  |
|||
| 3. Round | 07/02/2010 | River Plate | - | Rosario Central | 0:0 | ||||
| 4. Round | 15/02/2010 | Colón de Santa Fe | - | River Plate | 1:0 | ||||
| 5. Round | 21/02/2010 | River Plate | - | Arsenal de Sarandí | 1:1 | ||||
| 6. Round | 01/03/2010 | Gimnasia de La Plata | - | River Plate | 1:1 | ||||
| 7. Round | 04/03/2010 | River Plate | - | San Lorenzo | 1:0 | |
|||
| 8. Round | 07/03/2010 | Independiente | - | River Plate | 2:0 | ||||
| 9. Round | 14/03/2010 | River Plate | - | Huracán | 2:0 | ||||
| 10. Round | 25/03/2010 | Boca Juniors | - | River Plate | 2:0 | ||||
| 11. Round | 30/03/2010 | River Plate | - | Argentinos Juniors | 0:1 | |
|||
| 12. Round | 05/04/2010 | Lanús | - | River Plate | 1:0 |
Uruguay