| 2. Round | 29/07/2018 | Club León [U20] | - | CF Monterrey [U20] | 0:0 |  |
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| 3. Round | 05/08/2018 | Club Tijuana [U20] | - | Club León [U20] | 0:1 | ||||
| 4. Round | 11/08/2018 | Club León [U20] | - | Gallos Blancos [U20] | 0:1 | ||||
| 5. Round | 18/08/2018 | Cruz Azul [U20] | - | Club León [U20] | 2:1 | ||||
| 6. Round | 22/08/2018 | Club León [U20] | - | CF América [U20] | 2:1 | ||||
| 7. Round | 26/08/2018 | Deportivo Toluca [U20] | - | Club León [U20] | 0:1 | |
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| 8. Round | 01/09/2018 | Club León [U20] | - | Pumas UNAM [U20] | 1:0 | ||||
| 9. Round | 14/09/2018 | Santos Laguna [U20] | - | Club León [U20] | 3:4 |  |
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| 10. Round | 22/09/2018 | Club León [U20] | - | Lobos BUAP [U20] | 3:2 | ||||
| 11. Round | 28/09/2018 | CD Veracruz [U20] | - | Club León [U20] | 1:1 | ||||
| 12. Round | 06/10/2018 | Club León [U20] | - | Monarcas Morelia [U20] | 1:0 | ||||
| 13. Round | 20/10/2018 | Club Necaxa [U20] | - | Club León [U20] | 1:2 | ||||
| 14. Round | 28/10/2018 | Club León [U20] | - | Puebla FC [U20] | 4:1 | ||||
| 15. Round | 04/11/2018 | Atlas Guadalajara [U20] | - | Club León [U20] | 1:3 | ||||
| 16. Round | 10/11/2018 | Club León [U20] | - | Deportivo Guadalajara [U20] | 2:0 | |
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| 17. Round | 24/11/2018 | CF Pachuca [U20] | - | Club León [U20] | 3:1 |
Mexico