| 1. Round | 21/08/2010 | Fénix | - | Tacuarembó | 1:1 | ||||
| 2. Round | 29/08/2010 | Tacuarembó | - | El Tanque Sisley | 1:2 | ||||
| 4. Round | 19/09/2010 | Tacuarembó | - | Liverpool | 3:2 | ||||
| 5. Round | 25/09/2010 | River Plate | - | Tacuarembó | 2:0 | ||||
| 6. Round | 03/10/2010 | Tacuarembó | - | Miramar Misiones | 1:1 | ||||
| 7. Round | 10/10/2010 | Bella Vista | - | Tacuarembó | 3:2 |  |
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| 8. Round | 27/10/2010 | Tacuarembó | - | Peñarol | 1:5 | ||||
| 10. Round | 31/10/2010 | Tacuarembó | - | CA Cerro | 0:1 | ||||
| 13. Round | 21/11/2010 | Central Español | - | Tacuarembó | 1:0 | ||||
| 15. Round | 05/12/2010 | Tacuarembó | - | Defensor Sporting | 1:3 |
Uruguay