| 3. Round | 29/04/2022 | Técnico Universitario [U19] | - | Macará [U19] | 2:1 |  |
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| 4. Round | 07/05/2022 | Macará [U19] | - | América de Quito [U19] | 3:0 | ||||
| 5. Round | 14/05/2022 | Chacaritas FC [U19] | - | Macará [U19] | 1:2 | ||||
| 6. Round | 20/05/2022 | Macará [U19] | - | Cumbayá [U19] | 0:0 | ||||
| 8. Round | 04/06/2022 | Macará [U19] | - | El Nacional [U19] | 3:1 | ||||
| 9. Round | 10/06/2022 | Mushuc Runa [U19] | - | Macará [U19] | 4:3 | ||||
| 12. Round | 22/07/2022 | Macará [U19] | - | Chacaritas FC [U19] | 2:1 | ||||
| 13. Round | 29/07/2022 | Cumbayá [U19] | - | Macará [U19] | 0:0 | |
Ecuador