| 1. Round | 11/02/2022 | Newell's Old Boys | - | Defensa y Justicia | 1:0 | ||||
| 2. Round | 15/02/2022 | Argentinos Juniors | - | Newell's Old Boys | 3:0 | ||||
| 3. Round | 21/02/2022 | Newell's Old Boys | - | River Plate | 0:2 |  |
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| 4. Round | 28/02/2022 | Talleres de Córdoba | - | Newell's Old Boys | 1:2 | ||||
| 5. Round | 06/03/2022 | Newell's Old Boys | - | Atlético Tucumán | 4:0 |  |
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| 6. Round | 12/03/2022 | Sarmiento de Junín | - | Newell's Old Boys | 2:2 | ||||
| 7. Round | 20/03/2022 | Rosario Central | - | Newell's Old Boys | 0:1 | ||||
| 8. Round | 03/04/2022 | Newell's Old Boys | - | Platense | 3:1 | |
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| 9. Round | 09/04/2022 | Unión de Santa Fe | - | Newell's Old Boys | 1:0 | ||||
| 10. Round | 16/04/2022 | Newell's Old Boys | - | Patronato de Paraná | 1:0 | ||||
| 11. Round | 20/04/2022 | Newell's Old Boys | - | Banfield | 1:0 | ||||
| 12. Round | 24/04/2022 | Racing Club | - | Newell's Old Boys | 0:0 | ||||
| 13. Round | 28/04/2022 | Newell's Old Boys | - | San Lorenzo | 1:2 | ||||
| 14. Round | 08/05/2022 | Gimnasia de La Plata | - | Newell's Old Boys | 3:1 |
Argentina