| 2. Round | 16/01/2021 | Deportivo Guadalajara [U17] | - | Deportivo Toluca [U17] | 1:1 |  |
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| 3. Round | 21/01/2021 | Atlético San Luis [U17] | - | Deportivo Guadalajara [U17] | 0:3 | ||||
| 5. Round | 08/02/2021 | Club León [U17] | - | Deportivo Guadalajara [U17] | 2:2 | ||||
| 6. Round | 13/02/2021 | Deportivo Guadalajara [U17] | - | Club Necaxa [U17] | 2:2 | ||||
| 7. Round | 22/02/2021 | CF Pachuca [U17] | - | Deportivo Guadalajara [U17] | 3:1 | ||||
| 8. Round | 28/02/2021 | Deportivo Guadalajara [U17] | - | Pumas UNAM [U17] | 1:0 | ||||
| 9. Round | 03/03/2021 | Gallos Blancos [U17] | - | Deportivo Guadalajara [U17] | 2:3 |  |
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| 11. Round | 14/03/2021 | Deportivo Guadalajara [U17] | - | CF América [U17] | 3:0 |
Mexico